Circulating Isoprostanes
نویسندگان
چکیده
منابع مشابه
Isoprostanes.
The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes our current knowledge of these compounds. Herein, a historical account of their discovery and the mechanism of their formation are described. A specific class of IsoPs, the F2-IsoPs...
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Through reading textbooks on pathophysiology, medical students already learn during their early university years that cardiovascular disease (CVD) is closely associated with oxidative stress, which apparently promotes progression of diseases like atherosclerosis, diabetes mellitus, hypertension, and ischemic heart disease. Oxidative stress is created through reactive oxygen species (ROS), eg, t...
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F 2 -Isoprostanes are prostaglandin (PG) isomers formed in situ in cell membranes by peroxidation of arachidonic acid. 8-epi PGF 2 a and IPF 2 a -I are F 2 -isoprostanes produced in humans which circulate in plasma and are excreted in urine. Measurement of F 2 -isoprostanes may offer a sensitive, specific, and noninvasive method for measuring oxidant stress in clinical settings where reactive o...
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متن کاملCardiovascular pharmacology and physiology of the isoprostanes.
F(2)-isoprostanes are a complex family of compounds produced from arachidonic acid via a free radical-catalyzed mechanism. Their quantification as a pathophysiological biomarker provides a unique opportunity to investigate lipid peroxidation in vascular diseases. Their measurement also provides an interesting biomarker for the rational dose selection of antioxidants in vascular diseases where o...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2008
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.187278